Plasmid encoding microRNA-200c ameliorates periodontitis and systemic inflammation in obese mice

• Main Authors: Tadkamol Krongbaramee (Author), Min Zhu (Author), Qingwen Qian (Author), Zeyuan Zhang (Author), Steven Eliason (Author), Yi Shu (Author), Fang Qian (Author), Adil Akkouch (Author), Dan Su (Author), Brad A. Amendt (Author), Ling Yang (Author), Liu Hong (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study was conducted to characterize microRNA-200c (miR-200c) and its regulators in adipogenic differentiation, obesity, and periodontitis in obese subjects (PiOSs), and to determine the therapeutic efficacy of plasmid DNA encoding miR-200c as a treatment for PiOSs. We report that highly...