Fetal Tracheal Occlusion Increases Lung Basal Cells via Increased Yap Signaling

• Main Authors: Vincent Serapiglia (Author), Chad A. Stephens (Author), Rashika Joshi (Author), Emrah Aydin (Author), Marc Oria (Author), Mario Marotta (Author), Jose L. Peiro (Author), Brian M. Varisco (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fetal endoscopic tracheal occlusion (FETO) is an emerging surgical therapy for congenital diaphragmatic hernia (CDH). Ovine and rabbit data suggested altered lung epithelial cell populations after tracheal occlusion (TO) with transcriptomic signatures implicating basal cells. To test this hypothesis...