Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets

• Main Authors: Chenming Zeng (Author), Chenxi Zhao (Author), Fujing Ge (Author), Yuekang Li (Author), Ji Cao (Author), Meidan Ying (Author), Jinjian Lu (Author), Qiaojun He (Author), Bo Yang (Author), Xiaoyang Dai (Author), Hong Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ubiquitination is known as important post-translational modification in cancer-related pathways. Human deubiquitinases (DUBs), with functions of modulating the ubiquitination process, are a family with about 100 proteins. They mainly function by cutting ubiquitin chains of the substrates. The Machad...