Dietary medium-chain fatty acids reduce food intake via the GDF15-GFRAL axis in mice

• Main Authors: Josephine M. Kanta (Author), Luisa Deisen (Author), Kornelia Johann (Author), Stephanie Holm (Author), Annemarie Lundsgaard (Author), Jens Lund (Author), Markus Jähnert (Author), Annette Schürmann (Author), Christoffer Clemmensen (Author), Bente Kiens (Author), Andreas M. Fritzen (Author), Maximilian Kleinert (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Medium chain fatty acids (MCFAs), which are fatty acids with chain lengths of 8-12 carbon atoms, have been shown to reduce food intake in rodents and humans, but the underlying mechanisms are unknown. Unlike most other fatty acids, MCFAs are absorbed from the intestine into the portal vei...