MSC-Derived Exosomes Protect Vertebral Endplate Chondrocytes against Apoptosis and Calcification via the miR-31-5p/ATF6 Axis

• Main Authors: Lin Xie (Author), Zhenhao Chen (Author), Ming Liu (Author), Weibo Huang (Author), Fei Zou (Author), Xiaosheng Ma (Author), Jie Tao (Author), Jingkang Guo (Author), Xinlei Xia (Author), Feizhou Lyu (Author), Hongli Wang (Author), Chaojun Zheng (Author), Jianyuan Jiang (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Apoptosis and calcification of endplate chondrocytes (EPCs) can exacerbate intervertebral disc degeneration (IVDD). Mesenchymal stem cell-derived exosomes (MSC-exosomes) are reported to have the therapeutic potential in IVDD. However, the effects and related mechanisms of MSC-exosomes on EPCs are st...