Design, Synthesis, and Antitumor Evaluation of Novel Mono-Carbonyl Curcumin Analogs in Hepatocellular Carcinoma Cell

• Main Authors: Pan Yu (Author), Weiya Cao (Author), Linguo Zhao (Author), Qing Han (Author), Shilong Yang (Author), Kepeng Yang (Author), Xiaolei Pan (Author), Qianyun Wang (Author), Yuan Wang (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Curcumin is a polyphenolic natural product that has promising anticancer properties. However, its clinical utility is limited by its chemical instability and poor metabolic properties. In this paper, a series of new curcumin analogs were synthesized and found to be potent antiproliferative agents ag...