Solubility and dissolution studies of tibolone polymorphs

• Main Authors: Rudy Bonfilio (Author), Marília Cristina Oliveira Souza (Author), Jockastta Silva Leal (Author), Olímpia Maria Martins Santos Viana (Author), Antônio Carlos Doriguetto (Author), Magali Benjamin de Araújo (Author)
• Format: Bog
• Udgivet: Universidade de São Paulo, 2018-03-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

ABSTRACT Different solid forms of an active pharmaceutical ingredient can have distinct chemical and physical characteristics. In this work, we studied the solubility and dissolution properties of the described tibolone polymorphic forms (I and II). Both forms were successively recrystallized and ch...