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Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2

Background: Fcγ-receptor (FcγR)-independent enhancement of SARS-CoV-2 infection mediated by N-terminal domain (NTD)-binding monoclonal antibodies (mAbs) has been observed in vitro, but the functional significance of these antibodies in vivo is less clear.  Methods: We characterized 1,213 SARS-CoV-2...

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Prif Awduron: Ruth Connor (Awdur), Mrunal Sakharkar (Awdur), Garrett Rappazzo (Awdur), Chengzi Kaku (Awdur), Nicholas Curtis (Awdur), Seungmin Shin (Awdur), Wendy Wieland-Alter (Awdur), Jordan Wentworth (Awdur), Daniel Mielcarz (Awdur), Joshua Weiner (Awdur), Margaret Ackerman (Awdur), Laura Walker (Awdur), Jiwon Lee (Awdur), Peter Wright (Awdur)
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Cyhoeddwyd: Case Western Reserve University, 2024-06-01T00:00:00Z.
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