Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2

• Main Authors: Ruth Connor (Author), Mrunal Sakharkar (Author), Garrett Rappazzo (Author), Chengzi Kaku (Author), Nicholas Curtis (Author), Seungmin Shin (Author), Wendy Wieland-Alter (Author), Jordan Wentworth (Author), Daniel Mielcarz (Author), Joshua Weiner (Author), Margaret Ackerman (Author), Laura Walker (Author), Jiwon Lee (Author), Peter Wright (Author)
• Format: Book
• Published: Case Western Reserve University, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Fcγ-receptor (FcγR)-independent enhancement of SARS-CoV-2 infection mediated by N-terminal domain (NTD)-binding monoclonal antibodies (mAbs) has been observed in vitro, but the functional significance of these antibodies in vivo is less clear.  Methods: We characterized 1,213 SARS-CoV-2...