Stress and Vascular Responses: Oxidative Stress and Endothelial Dysfunction in the Insulin-Resistant State

• Main Authors: Kazuya Shinozaki (Author), Atsunori Kashiwagi (Author), Masahiro Masada (Author), Tomio Okamura (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although insulin-resistant states have been associated with endothelial dysfunction due to increased vascular oxidative stress, the underlying mechanisms are pooly understood. Recent experimental evidence suggests that tetrahydrobiopterin (BH4), the natural and essential cofactor of NO synthases (NO...