MIJ821 (onfasprodil) in healthy volunteers: First‐in‐human, randomized, placebo‐controlled study (single ascending dose and repeated intravenous dose)

• Main Authors: Baltazar Gomez‐Mancilla (Author), Jeffrey A. Levy (Author), Subramanian Ganesan (Author), Thomas Faller (Author), Gil Issachar (Author), Ziv Peremen (Author), Offir Laufer (Author), Revital Shani‐Hershkovich (Author), Kostas Biliouris (Author), Ela Walker (Author), Mark P. Healy (Author), Oleksandr Sverdlov (Author), Sachin Desai (Author), S. Nassir Ghaemi (Author), Jang‐Ho Cha (Author), Y. Gopi Shanker (Author)
• Format: Book
• Published: Wiley, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This single‐center study administered MIJ821 (onfasprodil) as an intravenous infusion to healthy volunteers and included two parts: a single ascending dose study (Part 1) and a repeated intravenous dose study (Part 2). Primary objective was to evaluate the safety and tolerability of single...