Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: study protocol

• Main Authors: Masatoshi Takagi (Author), Chitose Ogawa (Author), Yuki Aoki-Nogami (Author), Tomoko Iehara (Author), Eri Ishibashi (Author), Minoru Imai (Author), Tetsuro Kihara (Author), Kiyoshi Nobori (Author), Kazuhisa Hasebe (Author), Shuki Mizutani (Author), Toshimi Kimura (Author), Masashi Nagata (Author), Masato Yasuhara (Author), Kenichi Yoshimura (Author), Pariko Yorozu (Author), Hajime Hosoi (Author), Ryuji Koike (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background There is no established standard chemotherapy for recurrent pediatric solid tumors such as neuroblastoma and sarcoma. Since some of these tumor cells show dysfunctions in homologous recombination repair, the goal is to conduct a phase I study of olaparib, a poly(ADP-ribose) polym...