Impact of Implementing CYP2C19 Genotype-Guided Antiplatelet Therapy on P2Y12 Inhibitor Selection and Clinical Outcomes in Acute Coronary Syndrome Patients After Percutaneous Coronary Intervention: A Real-World Study in China

• Main Authors: Yi Zhang (Author), Xiu-Jin Shi (Author), Wen-Xing Peng (Author), Jia-Lun Han (Author), Bai-Di Lin (Author), Ru Zhang (Author), Yun-Nan Zhang (Author), Jia-Lin Yan (Author), Juan-Juan Wei (Author), Yi-Fan Wang (Author), Su-Wei Chen (Author), Nan Nan (Author), Zhen-Wei Fang (Author), Yong Zeng (Author), Yang Lin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: CYP2C19 loss-of-function (LOF) alleles reduce the effectiveness of clopidogrel in patients undergoing percutaneous coronary intervention for acute coronary syndrome. However, the clinical impact of implementing CYP2C19 gene-guided pharmacotherapy is unclear, especially among the Chinese...