Targeting the Integrated Stress Response in Cancer Therapy

• Main Authors: Xiaobing Tian (Author), Shengliang Zhang (Author), Lanlan Zhou (Author), Attila A. Seyhan (Author), Liz Hernandez Borrero (Author), Yiqun Zhang (Author), Wafik S. El-Deiry (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The integrated stress response (ISR) is an evolutionarily conserved intra-cellular signaling network which is activated in response to intrinsic and extrinsic stresses. Various stresses are sensed by four specialized kinases, PKR-like ER kinase (PERK), general control non-derepressible 2 (GCN2), dou...