Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice

• Main Authors: Judit Meyer-Kovac (Author), Isa Kolbe (Author), Lea Ehrhardt (Author), Alexei Leliavski (Author), Jana Husse (Author), Gabriela Salinas (Author), Thomas Lingner (Author), Anthony H. Tsang (Author), Johanna L. Barclay (Author), Henrik Oster (Author)
• Format: Book
• Published: Elsevier, 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to which altered feeding rhythms are causative for the...