Hepatic gene therapy rescues high-fat diet responses in circadian Clock mutant mice

• मुख्य लेखकों: Judit Meyer-Kovac (लेखक), Isa Kolbe (लेखक), Lea Ehrhardt (लेखक), Alexei Leliavski (लेखक), Jana Husse (लेखक), Gabriela Salinas (लेखक), Thomas Lingner (लेखक), Anthony H. Tsang (लेखक), Johanna L. Barclay (लेखक), Henrik Oster (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2017-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Objective: Circadian Clock gene mutant mice show dampened 24-h feeding rhythms and an increased sensitivity to high-fat diet (HFD) feeding. Restricting HFD access to the dark phase counteracts its obesogenic effect in wild-type mice. The extent to which altered feeding rhythms are causative for the...