Orphan G protein-coupled receptors: the ongoing search for a home

• Main Authors: Amie Jobe (Author), Ranjit Vijayan (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Fag: article
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G protein-coupled receptors (GPCRs) make up the largest receptor superfamily, accounting for 4% of protein-coding genes. Despite the prevalence of such transmembrane receptors, a significant number remain orphans, lacking identified endogenous ligands. Since their conception, the reverse pharmacolog...