Enhancing the Poor Flow and Tableting Problems of High Drug-Loading Formulation of Canagliflozin Using Continuous Green Granulation Process and Design-of-Experiment Approach

• Main Authors: Bjad K. Almutairy (Author), El-Sayed Khafagy (Author), Ahmed Alalaiwe (Author), Mohammed F. Aldawsari (Author), Saad M. Alshahrani (Author), Bader B. Alsulays (Author), Abdullah S. Alshetaili (Author), Sultan M. Alshehri (Author), Mohamed H. Fayed (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Maximization of drug-loading can significantly reduce the size of dosage form and consequently decrease the cost of manufacture. In this research, two challenges were addressed: poor flow and tableting problems of high-drug loading (>70%) formulation of canagliflozin (CNG), by adopting the moistu...