Novel dual inhibitor for targeting PIM1 and FGFR1 kinases inhibits colorectal cancer growth in vitro and patient-derived xenografts in vivo

• Main Authors: Fanxiang Yin (Author), Ran Zhao (Author), Dhilli Rao Gorja (Author), Xiaorong Fu (Author), Ning Lu (Author), Hai Huang (Author), Beibei Xu (Author), Hanyong Chen (Author), Jung-Hyun Shim (Author), Kangdong Liu (Author), Zhi Li (Author), Kyle Vaughn Laster (Author), Zigang Dong (Author), Mee-Hyun Lee (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Colorectal cancer (CRC) is the second most common cause of cancer-related death in the world. The pro-viral integration site for Moloney murine leukemia virus 1 (PIM1) is a proto-oncogene and belongs to the serine/threonine kinase family, which are involved in cell proliferation, migration, and apop...