Evaluation of atezolizumab immunogenicity: Clinical pharmacology (part 1)

• Main Authors: Benjamin Wu (Author), Nitzan Sternheim (Author), Priya Agarwal (Author), Julia Suchomel (Author), Shweta Vadhavkar (Author), Rene Bruno (Author), Marcus Ballinger (Author), Coen A. Bernaards (Author), Phyllis Chan (Author), Jane Ruppel (Author), Jin Jin (Author), Sandhya Girish (Author), Amita Joshi (Author), Valerie Quarmby (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Baseline patient characteristics and prognostic factors are important considerations in oncology when evaluating the impact of immunogenicity on pharmacokinetics (PK) and efficacy. Here, we assessed the impact of anti‐drug antibodies (ADA) on the PK of the immune checkpoint inhibitor atezol...