Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control

• Main Authors: Xin Wang (Author), Kaiyuan Deng (Author), Cheng Wang (Author), Yao Li (Author), Tianqi Wang (Author), Zhi Huang (Author), Yakun Ma (Author), Peiqing Sun (Author), Yi Shi (Author), Shengyong Yang (Author), Yan Fan (Author), Rong Xiang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation of cell transcription, were synthesised. A systematic study of enzymatic and cellular assays led to the identification of compound X22 with a nanomolar potency against CDK...