Lentiviral vectors for inducible, transactivator-free advanced therapy medicinal products: Application to CAR-T cells

• Main Authors: María Tristán-Manzano (Author), Noelia Maldonado-Pérez (Author), Pedro Justicia-Lirio (Author), Marina Cortijo-Gutierréz (Author), Pablo Tristán-Ramos (Author), Carlos Blanco-Benítez (Author), Kristina Pavlovic (Author), Araceli Aguilar-González (Author), Pilar Muñoz (Author), Francisco J. Molina-Estevez (Author), Valerie Griesche (Author), Juan Antonio Marchal (Author), Sara R. Heras (Author), Karim Benabdellah (Author), Francisco Martin (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Controlling transgene expression through an externally administered inductor is envisioned as a potent strategy to improve safety and efficacy of gene therapy approaches. Generally, inducible ON systems require a chimeric transcription factor (transactivator) that becomes activated by an inductor, w...