A versatile design platform for glycoengineering therapeutic antibodies

• Main Authors: Seth D. Ludwig (Author), Zachary J. Bernstein (Author), Christian Agatemor (Author), Kris Dammen-Brower (Author), Jeffrey Ruffolo (Author), Jonah M. Rosas (Author), Jeremy D. Post (Author), Robert N. Cole (Author), Kevin J. Yarema (Author), Jamie B. Spangler (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Manipulation of glycosylation patterns, i.e., glycoengineering, is incorporated in the therapeutic antibody development workflow to ensure clinical safety, and this approach has also been used to modulate the biological activities, functions, or pharmacological properties of antibody drugs. Whereas...