Overcoming the Low Oral Bioavailability of Deuterated Pyrazoloquinolinone Ligand DK-I-60-3 by Nanonization: A Knowledge-Based Approach

• Main Authors: Jelena R. Mitrović (Author), Branka Divović-Matović (Author), Daniel E. Knutson (Author), Jelena B. Đoković (Author), Aleksandar Kremenović (Author), Vladimir D. Dobričić (Author), Danijela V. Randjelović (Author), Ivana Pantelić (Author), James M. Cook (Author), Miroslav M. Savić (Author), Snežana D. Savić (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Poor water solubility of new chemical entities is considered as one of the main obstacles in drug development, as it usually leads to low bioavailability after administration. To overcome these problems, the selection of the appropriate formulation technology needs to be based on the physicochemical...