Novel Indole-Tethered Chromene Derivatives: Synthesis, Cytotoxic Properties, and Key Computational Insights

• Main Authors: M. Shaheer Malik (Author), Hissana Ather (Author), Shaik Mohammad Asif Ansari (Author), Ayesha Siddiqua (Author), Qazi Mohammad Sajid Jamal (Author), Ali H. Alharbi (Author), Munirah M. Al-Rooqi (Author), Rabab S. Jassas (Author), Essam M. Hussein (Author), Ziad Moussa (Author), Rami J. Obaid (Author), Saleh A. Ahmed (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Indole-tethered chromene derivatives were synthesised in a one-pot multicomponent reaction using <i>N</i>-alkyl-1<i>H</i>-indole-3-carbaldehydes, 5,5-dimethylcyclohexane-1,3-dione, and malononitrile, catalysed by DBU at 60-65 °C in a short reaction time. The benefits of the m...