Myc 9aaTAD activation domain binds to mediator of transcription with superior high affinity

• Main Authors: Andrea Knight (Author), Josef Houser (Author), Tomas Otasevic (Author), Vilem Juran (Author), Vaclav Vybihal (Author), Martin Smrcka (Author), Martin Piskacek (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The overexpression of MYC genes is frequently found in many human cancers, including adult and pediatric malignant brain tumors. Targeting MYC genes continues to be challenging due to their undruggable nature. Using our prediction algorithm, the nine-amino-acid activation domain (9aaTAD) ha...