Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators

• Asıl Yazarlar: Alessio Nocentini (Yazar), Doretta Cuffaro (Yazar), Lidia Ciccone (Yazar), Elisabetta Orlandini (Yazar), Susanna Nencetti (Yazar), Elisa Nuti (Yazar), Armando Rossello (Yazar), Claudiu T. Supuran (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The synthesis and carbonic anhydrase (CA; EC 4.2.1.1) activating effects of a series of oxime ether-based amino alcohols towards four human (h) CA isoforms expressed in human brain, hCA I, II, IV and VII, are described. Most investigated amino alcohol derivatives induced a consistent activation of t...