A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice

A Selective Neutraligand for CXCL12/SDF-1α With Beneficial Regulatory Functions in MRL/Lpr Lupus Prone Mice

Dysregulation of CXCL12/SDF-1-CXCR4/CD184 signaling is associated with inflammatory diseases and notably with systemic lupus erythematosus. Issued from the lead molecule chalcone-4, the first neutraligand of the CXCL12 chemokine, LIT-927 was recently described as a potent analogue with improved solu...

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Main Authors: Nicolas Schall (Author), François Daubeuf (Author), Claire Marsol (Author), Patrick Gizzi (Author), Nelly Frossard (Author), Dominique Bonnet (Author), Jean-Luc Galzi (Author), Sylviane Muller (Author)
Format: Book
Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
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