First-in-human study of a novel cell death tracer [99mTc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers

First-in-human study of a novel cell death tracer [99mTc]Tc-Duramycin: safety, biodistribution and radiation dosimetry in healthy volunteers

Abstract Background Imaging of cell death can provide an early indication of treatment response in cancer. [99mTc]Tc-Duramycin is a small-peptide SPECT tracer that recognizes both apoptotic and necrotic cells by binding to phosphatidylethanolamine present in the cell membrane. Preclinically, this tr...

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Main Authors: Taco Metelerkamp Cappenberg (Author), Stijn De Schepper (Author), Christel Vangestel (Author), Stef De Lombaerde (Author), Leonie wyffels (Author), Tim Van den Wyngaert (Author), Jeffrey Mattis (Author), Brian Gray (Author), Koon Pak (Author), Sigrid Stroobants (Author), Filipe Elvas (Author)
Format: Book
Published: SpringerOpen, 2023-08-01T00:00:00Z.
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