Isoxanthohumol improves obesity and glucose metabolism via inhibiting intestinal lipid absorption with a bloom of Akkermansia muciniphila in mice

• Main Authors: Yoshiyuki Watanabe (Author), Shiho Fujisaka (Author), Yoshitomo Morinaga (Author), Shiro Watanabe (Author), Allah Nawaz (Author), Hideki Hatta (Author), Tomonobu Kado (Author), Ayumi Nishimura (Author), Muhammad Bilal (Author), Muhammad Rahil Aslam (Author), Keiko Honda (Author), Yoshimi Nakagawa (Author), Samir Softic (Author), Kenichi Hirabayashi (Author), Takashi Nakagawa (Author), Yoshinori Nagai (Author), Kazuyuki Tobe (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Polyphenols have health-promoting effects, such as improving insulin resistance. Isoxanthohumol (IX), a prenylated flavonoid found in beer hops, has been suggested to reduce obesity and insulin resistance; however, the mechanism remains unknown. Methods: High-fat diet-fed mice were admini...