Assembling structurally customizable synthetic carriers of siRNA through thermodynamically self-regulated process

• Main Authors: Guang Bai (Author), Tong Xue (Author), Xiaotao Dong (Author), Uday Kumar Chinta (Author), Jia Feng (Author), Tuo Jin (Author), Fei Wu (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study demonstrates that our previously reported polywraplex, a synthetic siRNA carrier consisting of a uni-molecular polyplex core of customizable size and a self-assembled tri-block copolymer envelop, may be constructed using dendrimers as the crosslinking junctions. Replacing the branched low...