Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells

Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells

Gene therapy is a promising strategy to treat and cure most inherited metabolic liver disorders. Viral vectors such as those based on adeno-associated viruses (AAVs) and lentiviruses (LVs) are used as vehicles to deliver functional genes to affected hepatocytes. Adverse events associated with the us...

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Main Authors: Andoni Gómez-Moreno (Author), Enara San Sebastian (Author), Jennifer Moya (Author), Pilar Gomollón-Zueco (Author), Sergio Isola (Author), África Vales (Author), Gloria González-Aseguinolaza (Author), Carmen Unzu (Author), Urtzi Garaigorta (Author)
Format: Book
Published: MDPI AG, 2023-10-01T00:00:00Z.
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