Facilitation of TRKB Activation by the Angiotensin II Receptor Type-2 (AT2R) Agonist C21

• Main Authors: Liina Laukkanen (Author), Cassiano R. A. F. Diniz (Author), Sebastien Foulquier (Author), Jos Prickaerts (Author), Eero Castrén (Author), Plinio C. Casarotto (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Blockers of angiotensin II type 1 receptor (AT1R) exert antidepressant-like effects by indirectly facilitating the activation of the angiotensin II type 2 receptor (AT2R), which leads to increased surface expression and transactivation of tropomyosin-related kinase B receptors (TRKB). Compound 21 (C...