Improving Antibacterial Activity of a HtrA Protease Inhibitor JO146 against <i>Helicobacter pylori</i>: A Novel Approach Using Microfluidics-Engineered PLGA Nanoparticles

• Main Authors: Jimin Hwang (Author), Sonya Mros (Author), Allan B. Gamble (Author), Joel D. A. Tyndall (Author), Arlene McDowell (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nanoparticle drug delivery systems have emerged as a promising strategy for overcoming limitations of antimicrobial drugs such as stability, bioavailability, and insufficient exposure to the hard-to-reach bacterial drug targets. Although size is a vital colloidal feature of nanoparticles that govern...