Synthesis and Preclinical Evaluation of Radio-Iodinated GRPR/PSMA Bispecific Heterodimers for the Theranostics Application in Prostate Cancer

• Main Authors: Ayman Abouzayed (Author), Cheng-Bin Yim (Author), Bogdan Mitran (Author), Sara S. Rinne (Author), Vladimir Tolmachev (Author), Mats Larhed (Author), Ulrika Rosenström (Author), Anna Orlova (Author)
• Format: Book
• Published: MDPI AG, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gastrin-releasing peptide receptor (GRPR) and prostate-specific membrane antigen (PSMA) are overexpressed in most prostate cancers. GRPR expression is higher in early stages while PSMA expression increases with progression. The possibility of targeting both markers with a single theranostics radiotr...