Detection of leukemia gene fusions by targeted RNA-sequencing in routine diagnostics

• Main Authors: Marie Engvall (Author), Nicola Cahill (Author), Britt-Inger Jonsson (Author), Martin Höglund (Author), Helene Hallböök (Author), Lucia Cavelier (Author)
• Format: Book
• Published: BMC, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background We have evaluated an NGS-based method to detect recurrent gene fusions of diagnostic and prognostic importance in hematological malignancies. Our goal was to achieve a highly specific assay with a simple workflow, short turnaround time and low cost. Method The assay uses a commer...