Effect of <i>GSTA1</i> Variants on Busulfan-Based Conditioning Regimen Prior to Allogenic Hematopoietic Stem-Cell Transplantation in Pediatric Asians

• Main Authors: Ai-Hoc Nguyen (Author), Mohitosh Biswas (Author), Apichaya Puangpetch (Author), Santirhat Prommas (Author), Samart Pakakasama (Author), Usanarat Anurathapan (Author), Jiratha Rachanakul (Author), Rattanaporn Sukprasong (Author), Nutthan Nuntharadtanaphong (Author), Nutcha Jongjitsook (Author), Suradej Hongeng (Author), Chonlaphat Sukasem (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Busulfan is widely used as a chemotherapy treatment before hematopoietic stem-cell transplantation (HSCT). However, the response of busulfan is highly variable and unpredictable, whereby the pharmacogenetic interference of glutathione <i>S</i>-transferase (GST) has strong evidence in Cau...