Causal Effects of Body Mass Index on Airflow Obstruction and Forced Mid-Expiratory Flow: A Mendelian Randomization Study Taking Interactions and Age-Specific Instruments Into Consideration Toward a Life Course Perspective

• Main Authors: Nicole Probst-Hensch (Author), Ayoung Jeong (Author), Daiana Stolz (Author), Marco Pons (Author), Paola M. Soccal (Author), Robert Bettschart (Author), Deborah Jarvis (Author), John W. Holloway (Author), Florian Kronenberg (Author), Medea Imboden (Author), Christian Schindler (Author), Gianfranco F. Lovison (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity has complex links to respiratory health. Mendelian randomization (MR) enables assessment of causality of body mass index (BMI) effects on airflow obstruction and mid-expiratory flow. In the adult SAPALDIA cohort, recruiting 9,651 population-representative samples aged 18-60 years at baseline...