Activation of TRPA1 by membrane permeable local anesthetics

• Main Authors: Kronewald Sergej (Author), Lattrell Anja (Author), Leffler Andreas (Author), Niedermirtl Florian (Author), Nau Carla (Author)
• Format: Knjiga
• Izdano: SAGE Publishing, 2011-08-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Low concentrations of local anesthetics (LAs) suppress cellular excitability by inhibiting voltage-gated Na⁺channels. In contrast, LAs at high concentrations can be excitatory and neurotoxic. We recently demon...