Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors

• Главные авторы: Seok Jong Kang (Автор), Jung Wuk Lee (Автор), Jiho Song (Автор), Jiwon Park (Автор), Jaeyul Choi (Автор), Kwee Hyun Suh (Автор), Kyung Hoon Min (Автор)
• Формат: ‌
• Опубликовано: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Предметы: article
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The importance of transforming growth factor beta-activated kinase 1 (TAK1) to cell survival has been demonstrated in many studies. TAK1 regulates signalling cascades, the NF-κB pathway and the mitogen-activated protein kinase (MAPK) pathway. TAK1 inhibitors can induce the apoptosis of cancerous cel...