Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer's disease

• Main Authors: Chen Zhang (Author), Qian Zhou (Author), Xu-Nian Wu (Author), Ya-Dan Huang (Author), Jie Zhou (Author), Zengwei Lai (Author), Yinuo Wu (Author), Hai-Bin Luo (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Phosphodiesterase-9 (PDE9) is a promising target for treatment of Alzheimer's disease (AD). To discover multifunctional anti-AD agents with capability of PDE9 inhibition and antioxidant activity, a series of novel pyrazolopyrimidinone derivatives, coupling with the pharmacophore of antioxidants...