New (Iso)quinolinyl-pyridine-2,6-dicarboxamide G-Quadruplex Stabilizers. A Structure-Activity Relationship Study

• Main Authors: Enrico Cadoni (Author), Pedro R. Magalhães (Author), Rita M. Emídio (Author), Eduarda Mendes (Author), Jorge Vítor (Author), Josué Carvalho (Author), Carla Cruz (Author), Bruno L. Victor (Author), Alexandra Paulo (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G-quadruplex (G4)-interactive small molecules have a wide range of potential applications, not only as drugs, but also as sensors of quadruplex structures. The purpose of this work is the synthesis of analogues of the bis-methylquinolinium-pyridine-2,6-dicarboxamide G4 ligand 360A, to identify relev...