A Sensitization-Free Dimethyl Fumarate Prodrug, Isosorbide Di-(Methyl Fumarate), Provides a Topical Treatment Candidate for Psoriasis

• Glavni autori: Krzysztof Bojanowski (Autor), Collins U. Ibeji (Autor), Parvesh Singh (Autor), William R. Swindell (Autor), Ratan K. Chaudhuri (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2021-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Dimethyl fumarate (DMF) is an effective oral treatment for psoriasis administered in Europe for nearly 60 years. However, its potential has been limited by contact dermatitis that prohibits topical application. This paper characterizes a DMF derivative, isosorbide DMF (IDMF), which was designed to h...