Defective cell cycle checkpoints as targets for anti-cancer therapies

• 主要な著者: Brian eGabrielli (著者), Kelly eBrooks (著者), Sandra ePavey (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2012-02-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Conventional chemotherapeutics target the proliferating fraction of cells, which will include the tumour cells, but are also toxic to actively proliferating normal tissues. Cellular stresses, such as those imposed by chemotherapeutic drugs, induce cell cycle checkpoint arrest, and recent approaches...