Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents

• Main Authors: Yakumo Aoyama (Author), Satoshi Inagaki (Author), Kota Aoshima (Author), Yuki Iwata (Author), Shinsuke Nakamura (Author), Hideaki Hara (Author), Masamitsu Shimazawa (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leber hereditary optic neuropathy (LHON) is caused by mitochondrial DNA mutations and is the most common inherited mitochondrial disease. It is responsible for central vision loss in young adulthood. However, the precise mechanisms of onset are unknown. This study aimed to elucidate the mechanisms u...