Pathway mapping of leukocyte transcriptome in influenza patients reveals distinct pathogenic mechanisms associated with progression to severe infection

• Main Authors: Yoann Zerbib (Author), Emily K. Jenkins (Author), Maryam Shojaei (Author), Adrienne F. A. Meyers (Author), John Ho (Author), T. Blake Ball (Author), Yoav Keynan (Author), Amarnath Pisipati (Author), Aseem Kumar (Author), Anand Kumar (Author), Marek Nalos (Author), Benjamin M. Tang (Author), Klaus Schughart (Author), Anthony McLean (Author), on behalf of the Nepean Genomic Research Group (Author)
• Format: Book
• Published: BMC, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Influenza infections produce a spectrum of disease severity, ranging from a mild respiratory illness to respiratory failure and death. The host-response pathways associated with the progression to severe influenza disease are not well understood. Methods To gain insight into the...