N-type Calcium Channel Inhibition With Cilnidipine Elicits Glomerular Podocyte Protection Independent of Sympathetic Nerve Inhibition

• Main Authors: Bai Lei (Author), Daisuke Nakano (Author), Yoshihide Fujisawa (Author), Ya Liu (Author), Hirofumi Hitomi (Author), Hiroyuki Kobori (Author), Hirohito Mori (Author), Tsutomu Masaki (Author), Katsuhiko Asanuma (Author), Yasuhiko Tomino (Author), Akira Nishiyama (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We recently demonstrated that cilnidipine, an L/N-type calcium channel blocker, elicits protective effects against glomerular podocyte injury, in particular, in obese hypertensive rats that express the N-type calcium channel (N-CC). Since the N-CC is known to be expressed in sympathetic nerve ending...