RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection

• Main Authors: Samira Marx (Author), Beate M. Kümmerer (Author), Christian Grützner (Author), Hiroki Kato (Author), Martin Schlee (Author), Marcel Renn (Author), Eva Bartok (Author), Gunther Hartmann (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The SARS-CoV-2 pandemic has underscored the need for rapidly usable prophylactic and antiviral treatments against emerging viruses. The targeted stimulation of antiviral innate immune receptors can trigger a broad antiviral response that also acts against new, unknown viruses. Here, we used the K18-...