Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade

• Main Authors: Sara Marie Atkinson (Author), Ute Hoffmann (Author), Alf Hamann (Author), Emil Bach (Author), Niels Banhos Danneskiold-Samsøe (Author), Karsten Kristiansen (Author), Kyle Serikawa (Author), Brian Fox (Author), Kim Kruse (Author), Claus Haase (Author), Søren Skov (Author), Anneline Nansen (Author)
• Format: Book
• Published: The Company of Biologists, 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rodent models of arthritis have been extensively used in the elucidation of rheumatoid arthritis (RA) pathogenesis and are instrumental in the development of therapeutic strategies. Here we utilise delayed-type hypersensitivity arthritis (DTHA), a model in C57BL/6 mice affecting one paw with synchro...