Neoantimycin F, a Streptomyces-Derived Natural Product Induces Mitochondria-Related Apoptotic Death in Human Non-Small Cell Lung Cancer Cells

• Main Authors: Liyun Liu (Author), Hongrui Zhu (Author), Wei Wu (Author), Yaoyao Shen (Author), Xiao Lin (Author), Ying Wu (Author), Li Liu (Author), Jie Tang (Author), Yongjun Zhou (Author), Fan Sun (Author), Hou-Wen Lin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Streptomyces-derived natural products have been become a major focus of anti-tumor drug discovery studies. Neoantimycin F (NAT-F), was isolated from Streptomyces conglobatus by our group. Here, we examined the anti-cancer activities and its underlying molecular mechanisms implicated in NAT-F-induced...