Intracellular Delivery of Itaconate by Metal-Organic Framework-Anchored Hydrogel Microspheres for Osteoarthritis Therapy

• Main Authors: Han Yu (Author), Peng Ren (Author), Xuekang Pan (Author), Xinyu Zhang (Author), Jun Ma (Author), Jiayi Chen (Author), Jian Sheng (Author), Huanhuan Luo (Author), Huigen Lu (Author), Gang Chen (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment of osteoarthritis (OA) remains a significant clinical challenge. Itaconate (IA), an emerging regulator of intracellular inflammation and oxidative stress, may potentially be harnessed to treat OA. However, the short joint residence time, inefficient drug delivery, and cell-impermeable prop...