Potent anti-Toxoplasma gondii activity of 4-chlorophenylthioacetone-derived thiosemicarbazones: Involvement of CCR2 and CCR5 receptors and 5-lipoxygenase in the mode of action

• Main Authors: Rayane Aparecida Nonato Rabelo (Author), Diego Rodney Rodrigues de Assis (Author), Alexandre Almeida Oliveira (Author), César Luís Nascimento Barbosa (Author), Rafaela das Dores Pereira (Author), Ricardo Wagner de Almeida Vitor (Author), Wiliam César Bento Régis (Author), Mauro Martins Teixeira (Author), Heloísa Beraldo (Author), Fabiana Simão Machado (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Toxoplasmosis is a disease requiring therapeutic innovation, and thiosemicarbazones with antimicrobial activity are candidates to control Toxoplasma gondii infection. Here, the anti-T. gondii activities of (E)-2-(1-(4-chlorophenylthio)propan-2-ylidene)-hydrazinecarbothioamides (Ca and Cb) were inves...